She earned other pre-OITNBcredits forMercy,Atlas Shrugged: Part I,The Lucky One, andArgo.

She spent more than 10 years on the show, also earning credits forMrs.

Columbo,Heartbeat,Man of the People,Star Trek: Voyager, andNTSF:SD:SUV.

Taylor Schilling

JoJo Whilden/Netflix

The actress started her career in healthcare, picking up her first acting credits in her late 20s.

Polanco made her debut in the early 2010s, appearing in episodes ofUnforgettableandNYC 22.

Before landing the award-winning part, Aduba was primarily a stage actor, hitting Broadway inCoram BoyandGodspell.

Laura Prepon

Ron Galella/WireImage; JoJo Whilden/Netflix

The actress first appeared on television in 1994, booking a bit role onMatlock.

Michael Harney

Michael Harney finds his spot at Litchfield as corrections officer Sam Healy.

Harney earned his first on-screen credit two decades prior, debuting in a 1992 episode ofLaw & Order.

Kate Mulgrew

ABC Photo Archives/ABC via Getty Images; JoJo Whilden/Netflix

He went on to earn credits forTurbulence,NYPD Blue,Deadwood,Persons Unknown, andWeeds.

Selenis Leyva

Selenis Leyva plays Gloria Mendoza onOrange is the New Black, an inmate at Litchfield.

Stone earned her first acting credit in 1999 forMe Myself I, going on to appear inAll SaintsandSpirited.

Dascha Polanco

Johnny Nunez/WireImage; JoJo Whilden/Netflix

Samira Wiley

Samira Wiley joinedOITNBas inmate Poussey Washington.

Natasha Lyonne

A former child star, Natasha Lyonne plays Nicky Nichols onOrange Is the New Black.

The actress earned her first credits in the ’80s, appearing inPee-wee’s Playhouseas Opal.

Nick Sandow

NBC; JoJo Whilden/Netflix

Uzo Aduba

Joan Marcus; JoJo Whilden/Netflix

Lea DeLaria

ABC Photo Archives/ABC via Getty Images; JoJo Whilden/Netflix

Michael Harney

NBC; Netflix

Taryn Manning

JoJo Whilden/Netflix; Courtesy Everett Collection

Laverne Cox

VH1; JoJo Whilden/Netflix

Danielle Brooks

Jesse Grant/Getty Images; JoJo Whilden/Netflix

Selenis Leyva

NBC; JoJo Whilden/Netflix

Yael Stone

Sony Pictures/Courtesy Everett Collection; JoJo Whilden/Netflix

Samira Wiley

CBS; JoJo Whilden/Netflix

Natasha Lyonne

John D. Kisch/Separate Cinema Archive/Getty Images; JoJo Whilden/Netflix