Their relationship will visibly change forever, executive producer Jed Whedon tells EW.
Their chemistry is something that was conceived, in creating the characters, as two people who are inseparable.
Adorably, the partners dynamic mirrors that of Whedon and his wife and fellow EP Maurissa Tancharoens working relationship.

Credit: Eric McCandless/ABC
It was just something that involuntarily happened.
Because of the nature of that relationship, weve grown very fond of them.
We care very much about this unrequited love story that weve built since the beginning.
When we first conceived the characters, we didnt think it would go this way.
It was only in seeing them play it that their chemistry was so undeniable.
The trouble now is keeping that spark alive.
We always have to keep it complicated, Whedon says.
And we continue to do a good job of that moving forward.
Case in point: The rescue mission for Jemmas off-planet fling may dampen the honeymoon period.
Marvels Agents of S.H.I.E.L.D.airs Tuesdays at 9 p.m.